Sanctuary Relic Sigil
SANCTUARY RELICARPG Item Shop
Path of Exile 1Path of Exile 2Diablo 2 ResurrectedDiablo IV
Sell to Us
Login / Join
Path of Exile 1Path of Exile 2Diablo 2 ResurrectedDiablo IV
ᚱ
ᚦ
  1. Home
  2. Path of Exile 1
  3. Defiance Of Destiny - 20% Recoup Of Life

Defiance Of Destiny - 20% Recoup Of Life

Defiance Of Destiny - 20% Recoup Of Life
Unique ItemsUnique AccessoriesUnique Amulets
Defiance Of Destiny - 20% Recoup Of Life unique item for Path of Exile - Sanctuary Relic
Unavailable
Not priced for this selection
Select Platform/Realm/Mode before adding to cart.
Item Delivered As Described
Listing details checked before fulfillment
Fast Delivery
10 min 2 Hours
Service Guarantees
Instant Professional SupportAverage response time under 3 minutes via our 24/7 Live Chat or Discord.
Refund PolicyFull refund available if delivery is not completed within our guaranteed window.
Defiance Of Destiny - 20% Recoup Of Life
Unique ItemsUnique AccessoriesUnique Amulets

Variant Options

5 variants

Item Description

Defiance of Destiny

Paua Amulet

Requires Level 49

(20-30)% increased Mana Regeneration Rate

+(60-80) to maximum Life

+(10-40)% to Fire Resistance

+(10-40)% to Cold Resistance

+(10-40)% to Lightning Resistance

Gain 20% of Missing Unreserved Life before being Hit by an Enemy

Defiance Of Destiny - 20% Recoup Of Life unique item for 6981444ae5367158f90a0ce5 - Sanctuary Relic

Similar Items

Closest matches to this item.

Defiance Of Destiny - 20% Recoup Of Life, 100% Total Res
Defiance Of Destiny - 20% Recoup Of Life, 100% Total Res unique item for Path of Exile - Sanctuary Relic
From$0.99
Ships in 10 minutes 2 hours
View ItemView Options
Defiance Of Destiny - 16% Recoup Of Life, 100% Total Res
Defiance Of Destiny - 16% Recoup Of Life, 100% Total Res unique item for Path of Exile - Sanctuary Relic
From$4.95
Ships in 10 minutes 2 hours
View ItemView Options
Defiance Of Destiny - 27% Recoup Of Life
Defiance Of Destiny - 27% Recoup Of Life unique item for Path of Exile - Sanctuary Relic
From$0.99
Ships in 10 minutes 2 hours
View ItemView Options
Defiance Of Destiny - Random Roll
Defiance Of Destiny - Random Roll unique item for Path of Exile - Sanctuary Relic
New
From$4.46
Ships in 10 minutes 2 hours
View ItemView Options

People Also Buy

Popular related items in the same game and intent cluster.

Ashes Of The Stars - Random Roll
Ashes Of The Stars - Random Roll unique item for Path of Exile - Sanctuary Relic
New
From$0.99
Ships in 10 minutes 2 hours
View ItemView Options
Astramentis - Random Roll
Astramentis - Random Roll unique item for Path of Exile - Sanctuary Relic
New
From$0.49
Ships in 10 minutes 2 hours
View ItemView Options
Atziri's Foible - Random Roll
Atziri'S Foible - Random Roll unique item for Path of Exile - Sanctuary Relic
New
From$0.49
Ships in 10 minutes 2 hours
View ItemView Options
Badge Of The Brotherhood - Random Roll
Badge Of The Brotherhood - Random Roll unique item for Path of Exile - Sanctuary Relic
New
From$0.49
Ships in 10 minutes 2 hours
View ItemView Options
Carnage Heart - High Roll
Carnage Heart - High Roll unique item for Path of Exile - Sanctuary Relic
New
From$0.49
Ships in 10 minutes 2 hours
View ItemView Options
Carnage Heart - Random Roll
Carnage Heart - Random Roll unique item for Path of Exile - Sanctuary Relic
New
From$0.49
Ships in 10 minutes 2 hours
View ItemView Options
Crystallised Omniscience - Random Roll
Crystallised Omniscience - Random Roll unique item for Path of Exile - Sanctuary Relic
New
From$0.49
Ships in 10 minutes 2 hours
View ItemView Options
Daresso's Salute
Daresso'S Salute unique item for Path of Exile - Sanctuary Relic
New
From$0.49
Ships in 10 minutes 2 hours
Select core first

Related Guides

Articles connected to this product's game and use-case.

PoE 2 Unique Item Buying Checklist

A quick checklist for buying PoE 2 unique items, including rolls, variants, corruption, and build fit.

Need custom items?

Open live help and tell us what you need.

Unavailable
Not priced for this selection
Sanctuary Relic Sigil
Sanctuary Relic

The premiere destination for legendary artifacts across the multiverse. Safe, secure, and always epic.

P

Shop

  • Home
  • About
  • Help Center & FAQ
  • Buyer Guides
  • Blog
  • Sell to Us

Legal

  • Terms of Service
  • Privacy Policy
  • Refund Policy
  • Data Deletion
  • Sitemap

Support

Email Us

support@sanctuaryrelic.com

Our typical response time is under 12 hours. Need immediate help? Use our live chat.

© 2026 Sanctuary Relic. All rights reserved.

Made with for the community

Sanctuary Relic is an independent shop and is not affiliated with any game publisher or platform. Using third-party in-game services may violate game Terms of Use and can lead to account penalties, including suspension or termination.