Buyer answer
Lo is best for players building around physical damage, weapon pressure, or a major armor upgrade like Fortitude.
Grief and Fortitude are the cleanest Lo targets, especially for melee builds, mercenary armor, and physical damage setups.
Lo also appears in Phoenix, Doom, Dragon, Ice, Pride, Hand of Justice, Brand, and Destruction for more specialized builds.
By itself, Lo gives Deadly Strike in weapons, so it matters most when extra physical damage scaling is worth the socket.
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