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Buyer answer
Ist is best when you want a practical upgrade rune: it can finish major recipes or add direct Magic Find to a farming setup.
Socketing Ist gives Magic Find directly, making it useful for farming weapons, helms, armor, or shields when the socket is worth spending.
Common targets include Call to Arms, Infinity, Chains of Honor, Exile, Delirium, Silence, and Obsession.
Use it for MF only when the item will stay in your farming setup; otherwise save Ist for a recipe that changes the build.
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